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Keywords: FOXO4-DRI, Leydig cell, senescence, male late-onset hypogonadism, senolytics INTRODUCTION Male late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age

By neutralizing free radicals, it helps protect against oxidative stress, which can contribute to various health conditions, including inflammation, neurodegenerative diseases, and chronic illnesses

doi: 10.3390/ijms23042019 225 MouraRAFonsecaJE

John's Wort Streptomycin Streptozocin Substance Abuse Treatment Agents Succimer Sulfadiazine Sulfadoxine-Pyrimethamine Sulfasalazine Sulfonamides Sulfonylureas Sulfonylureas, First Generation Sulfonylureas, Second Generation Sulindac Sunitinib Suvorexant Suzetrigine T Tacrine Tacrolimus Tadalafil Tafamidis Tafasitamab Tafenoquine Tagraxofusp Talazoparib Tamoxifen Tamsulosin Tara Flour Tasimelteon Taxanes Tazemetostat Tebentafusp Teclistamab Tecovirimat Tedizolid Telaprevir Telbivudine Telithromycin Telmisartan Telotristat Temazepam Temozolomide Temsirolimus Tenapanor Tenofovir Teplizumab Tepotinib Teprotumumab Terazosin Terbinafine Teriflunomide Teriparatide Tesamorelin Tetracycline Tetracyclines Tezepelumab Thalidomide Theophylline Thiabendazole Thiazide Diuretics Thiazolidinediones Thioguanine Thioridazine Thiotepa Thrombopoietin Receptor Agonists Thyroid Hormone Tiagabine Tibolone Ticagrelor Ticarcillin Ticarcillin-Clavulanate Ticlopidine Tigecycline Tildrakizumab Timolol Tinidazole Tinospora Tiotropium Tirzepatide Tisotumab Vedotin Tivozanib Tizanidine Tobramycin Tocilizumab Tofacitinib Tofersen Tolcapone Tolmetin Tolterodine Tolvaptan Tongkat Ali Topiramate Topoisomerase Inhibitors Toremifene Tositumomab Tovorafenib Trabectedin Trace Elements and Metals Tralokinumab Tramadol Trametinib Trandolapril Transplant Agents Tranylcypromine Trastuzumab Trastuzumab Deruxtecan Trastuzumab Emtansine Trazodone Tremelimumab Triamterene Triazolam Tribulus Triclabendazole Trientine Trifluoperazine Trifluridine Triheptanoin Trihexyphenidyl Trilaciclib Trimethobenzamide Trimethoprim-Sulfamethoxazole Trimetrexate Trimipramine Triprolidine Triptorelin Trisalicylate Troglitazone Trospium Tucatinib Tumor Necrosis Factor Antagonists Turmeric U Ublituximab Ubrogepant Umbralisib Upadacitinib Ursodiol (Ursodeoxycholic Acid) Usnic Acid Ustekinumab Uva Ursi V Valacyclovir Valerian Valproate Valsartan Vancomycin Vandetanib Vardenafil Varenicline Vedolizumab Vemurafenib Venetoclax Venlafaxine, Desvenlafaxine Verapamil Vericiguat Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors Vibegron Viekira Pak Vigabatrin Vilazodone Viloxazine Viltolarsen Vinca Alkaloids Vismodegib Vitamin A Vitamin B Vitamin C Vitamin D Vitamin E Vitamin K Vitamins Voclosporin Vorapaxar Voriconazole Vorinostat Vortioxetine Vosoritide Voxelotor Vutrisiran W Warfarin Weight Loss Agents Wilson Disease Agents X Xanthine Derivatives Y Yerba Mate Yohimbine Z Zafirlukast Zaleplon Zanamivir Zanubrutinib Zavegepant Zepatier Zidovudine Zileuton Zinc Ziprasidone Zoliflodacin Zolpidem Zonisamide A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Disclaimer: Information presented in the LiverTox database is derived from the scientific literature and public databases and reflects professional expertise of the authors

On the contrary, it acts as a compulsory exchanger, mediating the influx of leucine into the cell and the efflux of glutamine out of the cell [29, 42]