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GLP-1 receptor agonists (e.g., semaglutide, dulaglutide, liraglutide) work by mimicking natural GLP-1 hormone to stimulate insulin secretion, suppress glucagon, slow gastric emptying, and promote satiety

A weight loss plateau on GLP-1s is often due to metabolic adaptation, also known as adaptive thermogenesis, where your body adjusts to a lower weight by burning fewer calories

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The body can make some peptides on its own