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2,9 In contrast to other agents in the class, 7 however, early studies in animal models demonstrated that linagliptin is almost completely (99%) bound to plasma proteins (mainly the DPP-4 enzyme) at the 5 mg therapeutic concentration, perhaps because of its high binding affinity and nonpolar surface area

But on April 7, when the study came out, much of the media unfortunately went overboard

Furthermore, alongside the increasing prevalence of related cardiometabolic diseases such as diabetes, obesity and chronic kidney disease (CKD), the number of people with HF has increased to around 64 million globally, amongst whom most are also living with type 2 diabetes or obesity ( Within the past 2 decades, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have emerged as effective agents to improve glycaemic control in type 2 diabetes and to reduce body weight in people with overweight or obesity (Sattar et al., 2021

In transgenic mouse models of AD, allopregnanolone increases neurogenesis, reduces amyloid deposition, and improves learning and memory [85]