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During ferroptosis, ROS are produced from the Fenton reaction, which is a process of producing hydroxide (OH ) and hydroxyl (OH ) by the reaction between Fe 2+ and H 2 O 2 ( 3+ is reduced to Fe 2+ through the reaction with superoxide (O 2 ), and Fe 2+ reacts with H 2 O 2 to form OH , OH , and Fe 3+ ( 2+ is conducive to the production of ROS and promotes lipid peroxidation, thus inducing ferroptosis

Researchers who maintain this consistent concentration across vial sizes eliminate a major source of dosing errors