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Response: We appreciate the commenter for the feedback regarding PRO-PMs and the scope of quality measures in the ASM heart failure measure set

61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent

It facilitates cell migration to injury sites, promotes cell differentiation, supports actin-mediated tissue remodeling, and reduces scar tissue formation

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