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Importantly, classifiers constructed on functional metagenomic characteristics (e.g., butyrate synthesis pathways, LPS biosynthesis genes) outperformed those based merely on taxonomy [188]

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Although monobody clone #3 formed a ternary complex with OPTN and TBK1 (Fig 6h), it prevented OPTN from accumulating, which abolished formation of the mitophagic contact site and subsequent TBK1 autophosphorylation