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If the safety profile holds through Phase 3 completion, retatrutide would give Lilly a generational lead: a next-generation drug arriving before most competitors have even received first approvals for their current-generation candidates

However, emerging concerns about mental health impacts warrant careful consideration

Patients with severe neurological complications from SARS-CoV-2 infection have an increased CSF Q-albumin ratio indicating BBB disruption, coupled with elevated CSF proteins, such as IL-8, which are associated with BBB disruption 65

Expanded Therapeutic Applications Cardiovascular and Chronic Kidney Disease: Ongoing research aims to expand the use of GLP-1 RAs in managing cardiovascular diseases and chronic kidney disease, offering potential for further market expansion

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