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These improvements were typically accompanied by increases in sex hormone-binding globulin (SHBG) due to improved insulin sensitivity, which affects the interpretation of total versus free testosterone measurements

Convenient once-weekly injection : Like other medication in this class, retatrutide is a once-a-week injection that is easier to adhere to than daily treatments

Thyroid function tests should be performed at baseline, repeated at 812 weeks after starting GLP-1 therapy, then every 36 months during active weight loss

"Illegal versions of the drugs today do not cannibalize Novo's sales given they are selling every dose they can produce," said Nicholas Anderson, portfolio manager and managing director at global asset management firm Thornburg Investment Management, which owns Novo Nordisk stocks

The more recent STEP UP trial tested a higher dose of 7.2 mg and showed average weight loss of 20.7% at 72 weeks