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Some patients prefer evening or bedtime administration, while others prefer morning

For patients taking orlistat, maintaining a low-fat diet is especially important, as eating high-fat foods can worsen gastrointestinal side effects

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Cox K, Rai R, Distler M, Daugherty JR, Coffman JA, Cooper TG

Key points: The lower doses of semaglutide can wear off after 4-5 days It can take up to 4-5 weeks for the medication to reach a steady state where its levels are consistent in the blood Weight loss may be steady at the beginning but become more consistent as you increase your dose Practical strategies to enhance semaglutide results in the UK Nutrition tips Prioritise protein at every meal (aim for 1.6-2g per kg of body weight daily) Stay well-hydrated (2-3 litres daily) to manage common side effects Consider splitting meals into smaller, more frequent portions if you feel full quickly Limit ultra-processed foods which may trigger cravings despite medication Physical activity guidance Include resistance training 2-3 times weekly to preserve muscle mass Aim to move a little bit each day, even a 5 minute walk as developing the habit of movement is more important than rigid targets when first starting Try exercise snacking, like calf raises when the kettle is boiling, or push-ups when youve been to the toilet Planning for the future Develop strategies for maintaining weight loss after treatment Learn how to safely transition off semaglutide when the time comes Frequently asked questions How do I access semaglutide on the NHS in the UK