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More specifically, osteoarthritis: painful joints, loss of mobility, difficulty getting up, and pain that can no longer be managed well enough

Its contribution to weight loss is less straightforward than GLP-1's and is still an active area of research, but targeting both receptors simultaneously appears to produce greater weight reduction than GLP-1 alone, which is the basis for tirzepatide's dual mechanism

However, any loss of lean mass matters because it can affect physical function, fracture risk and how well the body maintains weight and metabolic health over time

But here is where Wegovy and Saxenda and the others could fail to cause weight loss