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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

doi: 10.1016/j.crtox.2024.100170

Terry Wahls

Tear fluid was collected from 60 participants, cognitively normal (CN) individuals ( n = 32), patients with mild cognitive impairment ( n = 14), and dementia ( n = 14)

Common symptoms include: Persistent fatigue Low energy levels Shortness of breath Dizziness or feeling faint Irregular heartbeats (palpitations) Pale or yellowish skin Reduced appetite or unintentional weight loss If left untreated, B12 deficiency can lead to serious complications, including nerve damage, cognitive issues, and changes in mood