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Lancet Diabetes Endocrinol 6(4):275286

These consultations allow monitoring of: Glycaemic control through HbA1c measurements (usually every 36 months) Weight changes and body composition Tolerability and adverse effects , particularly gastrointestinal symptoms Blood pressure and heart rate Renal function tests NICE recommends (NG28) that GLP-1 therapy should be continued only if there is demonstrable benefittypically defined as an HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at six months for diabetes indications

Adashi, E

- Mechanism of Action: Alpha Arbutin inhibits tyrosinase activity similarly to Vitamin C but in a milder way

& Exton, J