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Notch signaling Notch receptors (Notch14) are activated by membrane-bound ligands (Jagged12, Delta-like14)

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He, L., & Shen, Y

The brain requires a very large amount of energy for its function, and these defects suggest that the aging brain is starved of energy, which could result in cognition decline. GlyNAC supplementation in old mice corrected brain glutathione deficiency, improved brain glucose transporters, reversed mitochondrial dysfunction and improved cognition