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In addition, IL-4 / mice had decreased production of tumor necrosis factor , CXCL1 and interleukin-1 in the liver, but not in a remote site such as the lungs

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Despite the potential of TNF- ablation therapies, caution is required in their application because TNF- is critical for the anti-tumor activity of cytotoxic NK and T cells, and its complete neutralization may inadvertently impair these immune cells functions

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