In the technical scheme of the invention, in the step (2), the substitution degree range of the solid-phase resin is 0.2-1.0mmol/g, and the condensing agent adopted for coupling is a combination of HOBt, DIC and DMAP, a combination of HOBt, DCC and DMAP, a combination of HOAt, DIC and DMAP, a combination of HBTU, HOBt and DIPEA, a combination of TBTU, HOBt and DIPEA, and a combination of PyBOP, HOBt and DIPEA

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Ginsberg HN, MacCallum PR
With respect to dosage, the National Institute for Healthcare and Excellence (NICE) recommends 0.25mg once a week for 4 weeks
a) Alpha cells b) Beta cells c) L-cells d) K-cells Answer: c) L-cells GLP-1 secretion is stimulated by: a) Fasting b) Stress c) Food intake d) Exercise Answer: c) Food intake One major function of GLP-1 is to: a) Increase glucagon b) Inhibit insulin c) Stimulate glucose-dependent insulin release d) Stimulate lipolysis Answer: c) Stimulate glucose-dependent insulin release GLP-1 slows: a) Hepatic metabolism b) Gastric emptying c) Renal excretion d) CNS transmission Answer: b) Gastric emptying The enzyme that rapidly degrades GLP-1 is: a) MAO-B b) COMT c) DPP-4 d) PKA Answer: c) DPP-4 Which of the following is a central effect of GLP-1