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The early role of UPR is to reduce translation to lessen the need for new protein folding, degrade unfolded proteins to minimize damage, and increase the expression of chaperone proteins to assist protein folding

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The BBB, which is primarily composed of brain microvascular endothelial cells (BMVECs) in close association with astrocytic endfeet, serves as the principal gateway that stringently controls the entry of iron into the brain parenchyma ( 3+ dissociates from transferrin and is reduced to its ferrous form Fe 2+ prior to its transport into the cytosol via DMT1

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