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Because a single ferroptosis pathway is more likely to trigger resistance to ferroptosis, multiple pathways should be coupled to promote ferroptosis in tumor cells at the same time

E.et al (2015)

Adhesions can also obliterate normal pelvic angles and induce abnormal uterine flexion, while nodularity and thickening of pelvic ligaments (uterosacral ligaments) with fibrotic reactions further disrupt pelvic anatomy ( Mechanically, these changes impair fertility through multiple pathways: extensive adhesions can occlude the tubal ostium and embed ovaries, blocking sperm passage and oocyte release

One may suggest that Nrf2 activation is specific to the disulfide forms of thiamine, not inherent in thiamine itself, as only the thiamine disulfides undergo intracellular reduction

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