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In the definitive SURMOUNT-5 head-to-head trial (NEJM 2025), tirzepatide produced ~20% weight loss vs

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Significant changes in body weight, calorie intake, and hormone balance can influence the menstrual cycle and lead to delayed periods, lighter bleeding, or irregular menstruation

[15] [16] The effects on tolerability with extended dosing intervals have not been systematically studied

We tried exercise, like walking 35 minutes a day, she recalled