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In general, disordered domains are unsuitable targets for potent peptide binding because of the lack of well-defined binding surfaces, conformational flexibility, and associated entropic penalties 60,61

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There is no adequately controlled human efficacy or safety literature for either molecule as a muscle agent, and their use as unapproved substances carries risks that fall entirely outside the scope of what the research can address

In conclusion, this evidence suggests ZnT2 serves as an innovative modulator for mucosal inflammation in colonic cells and plays a crucial role in coping with infectious colitis, opening up possibilities on manipulating ZnT2 as a novel treatment strategy to particular intestinal infections