Activation of GLP-1R by exendin-4 promoted the osteogenic differentiation, increased bone formation and osteoblast number and inhibited BMSC adipogenic differentiation, but wortmannin (PI3K inhibitor), and GLP-1R sh-RNA partially blocked the exendin-4-induced PI3K/AKT signaling activation and attenuated the facilitating effect of exendin-4 in BMSCs (Figure 1)
Vakifahmetoglu-Norberg H, Xia HG, Yuan J
#glp #glp1journey #tirzepatide #healthy #goals Week 6 on my GLP-1 #gettoknowme #glp1 #trending #weightloss #glp1support 12 pounds down after 3 weeks
Work with your provider to find a titration schedule that balances effectiveness with tolerability
Dai L, Trillo-Tinoco J, Cao Y, Bonstaff K, Doyle L, Del Valle L, Whitby D, Parsons C, Reiss K, Zabaleta J, et al