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When you have an autoimmune disease, you often feel exhausted no matter how much you rest
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Neurochem Int 56:611619 Karunakaran D, Diwakar L, Saeed U, Agarwal V, Ramikrishnan S, Iyengar S et al (2007) Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinsons disease: protection by alpha lipoic acid
Further, neuroinflammation can induce the increased expression and activity of NADPH oxidase, leading to a highly oxidative environment
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10.1172/JCI26640
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