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Fat tissue releases hormones that cause inflammation throughout the body

TEAD1 activity is modulated by alternative splicing (AS), with the exclusion of the inhibitory exon 5, resulting in increased expression and activity of TEAD1 DeltaEx5 , leading to HSC activation (See scheme)

When semaglutide activates these pathways, some patients experience heightened sensitivity to dehydration, signaling your brain that fluid intake is needed even if your body's actual hydration status is adequate

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