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The progression from inflammation to fibrosis is primarily mediated by hepatic stellate cell (HSC) activation, which involves two core mechanisms: the Transforming Growth Factor-beta 1 (TGF-1) - Mothers Against Decapentaplegic Homolog 3 (Smad3) pathway and Platelet-Derived Growth Factor (PDGF) -driven epithelial-mesenchymal transition (EMT) 52 , Furthermore, Wnt ligands released by apoptotic bodies promote HSC proliferation through -catenin nuclear translocation 53

[DOI] [PubMed] [Google Scholar] 46.Allerton T.D., Proctor D.N., Stephens J.M., Dugas T.R., Spielmann G., Irving B.A

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ET 50 represents the treatment time to achieve half of E max from carnitine supplementation on body weight in patients with PCOS