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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (355) to translocate into the brain and promote inflammation ( Figure 10 )

Testosterone further enhances these results by increasing muscle and reducing fat mass (1)

Otros mecanismos indirectos incluyen las modificaciones de los niveles circulantes de insulina, glucagn y adenosn trifosfato que regulan tambin la expresin del NHE3 y de los transportadores de sodio glucosa (SGLT) 25 , as como un efecto inhibitorio simptico a nivel central con estimulacin de la diuresis y la natriuresis 25 , 26 (Figura 3)

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