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Lower binding energy between the macromolecular protein and small molecule ligand indicates a higher binding probability and stability

The concentrated solution was dialyzed with deionized water for 72 h, and then lyophilized to obtain D-P (yield: 90%)

Since osteoporosis and obesity are two diseases that affect a vast majority of postmenopausal women concomitantly, using a single drug that is Food and Drug Administration (FDA) approved for obesity to prevent and manage both osteoporosis and obesity could improve the quality of life and decrease the complications and medical costs that occur as a result of both diseases

This is a pattern I'm seeing in clinical practice as a bench pharmacist

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Liu J., Conde K., Zhang P., et al