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Most gastrointestinal effects are dose-dependent and tend to improve as the body adjusts over the first four to eight weeks
Retatrutide is an unapproved investigational triple agonist (GLP-1, GIP, glucagon receptors) not licensed by the MHRA, EMA, or FDA for routine clinical use
Confirm frequency adherence
Although a recent meta-analysis showed an increased risk of GRC and aborted EGDs with GLP-1 RA use, it could not definitively establish a link to aspiration events due to limited data
