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Additionally, the same study reported a decrease in cigarette smoking among participants who were smokers, suggesting potential cross-substance benefits of GLP-1RAs in this population (Hendershot et al., 2025)
But within those medications, there is an important distinction: standard-dose protocols are designed for stronger appetite suppression and more traditional weight loss titration, while microdose protocols use lower-dose strategies intended to be gentler, more gradual, and often easier to tolerate
95% confidence interval, 0.72 to 0.90
Science 385 , 258260 (2024)
Agency for Healthcare Research and Quality [online] (2013)
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