semaglutide and severe constipation GLP-1 medications like tirzepatide are on the rise, but so are accidental overdoses of these medications. Poison control centers have seen a massive surge in calls regarding weight-loss and diabetes Severe constipation is never OK

Within the emerging geroscience paradigm 2 , pharmacologic agents originally developed for metabolic indications, such as GLP-1 receptor agonists 3,4,5,6 , have garnered attention due to their potential dual roles in metabolic regulation and aging biology 7

Moreover, GLP-1 could down-regulate ANG II production at tissue level (71) indeed reported that chronic treatment with GLP-1RA exendin 4 (Ex4) in rats decreased renal cortical ANG II content and urinary excretion of AGT, while blockade of GLP-1 receptor with exendin 9 (Ex9) exerted opposite effects

Taken together, these effects suggest that semaglutide isnt just helping people lose weight

Early detection and treatment are crucial to prevent more serious health problems

This led to the demonstration that DPP-4 inhibitors may protect the endogenous molecule [14] and to the development of clinically useful DPP-4 inhibitors, which have found clinical use worldwide