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Unlike markets where direct-to-consumer advertising drives demand, German growth is guideline-aligned and outcomes-dependent, with cardiometabolic evidence packages determining formulary positioning

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Semaglutide works by activating GLP-1 receptors in your brain's appetite center, a mechanism that begins within hours of injection but takes days to weeks to produce noticeable hunger reduction

This dual effectmedication-driven metabolic shift plus weight-loss-related insulation lossexplains why cold sensitivity often emerges during the first weeks of treatment when weight loss accelerates