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Elevated levels of IgM and IgA antibodies to one potent MAMP- exotoxin lipopolysaccharide (LPS)- have been observed in ME/CFS (205), as well as higher blood levels of bacterial LPS, LPS-binding proteins, and soluble CD14 (191)

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Viral spike proteins, persistent inflammatory cytokines, and circulating autoantibodies create a highly toxic environment that impairs the enzyme responsible for making NO, known as endothelial nitric oxide synthase (eNOS)

The number of the rings of the inflammatory cells infiltrating around the airways, which were assessed as inflammation scores, was significantly higher in the OVA group compared with the control group (Fig