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The strongest clinical use cases are musculoskeletal injuries, gut lining integrity, and systemic inflammation

182 Although it is not clear whether there is crosstalk between diabetes and PD in neurogenesis, similar pathophysiological changes may indicate a close association between the two diseases

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decreased leptin, peptide YY, cholecystokinin, amylin, insulin and glucagon-like peptide-1) 31 , compensatory changes to energy homoeostasis (decreased energy expenditure due to reduced body mass and enhanced metabolic efficiency) 32 , altered nutrient metabolism that can alter energy homeostasis 33 ) and subjective changes in appetite (e.g