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Clinicians should monitor thyroid function tests (TSH, free T4) at: Baseline before starting weight loss injections 6-8 weeks after achieving maintenance dose Every 3-6 months during active weight loss After significant weight stabilization Symptoms of overreplacement (palpitations, anxiety, tremor, heat intolerance) should prompt earlier testing
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However, the bodys naturally produced GLP-1 has a very short half-life, lasting only a few minutes before it is rapidly broken down by an enzyme called dipeptidyl peptidase-4 (DPP-4)
Patients with a history of pancreatitis (inflammation of the pancreas) or those who have had thyroid cancer or a family history of medullary thyroid cancer should avoid semaglutide due to potential risks
Case report and literature review
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