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In addition, heterogenous tumors are composed of multiple subpopulations associated with different proliferative and malignant potentials [36]

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Mounjaro was FDA-approved in 2022 for type 2 diabetes, while Zepbound received FDA approval in November 2023 for chronic weight management

The genetic correlates relate primarily to variants in the genes coding for transporters controlling plasma UA, yet such presumed functional variants will also influence, through the same proteins, the transport of UA into the brain and subsequently into neurons and glia, as described below

Our sensitivity analysis with exenatide suggests that NAION may be unique to semaglutide, indicating a mechanism beyond transient glucose reductions associated with GLP-1 RAs. The growing compendium of research exposing the ocular risks associated with GLP-1 RAs is concerning as the popularity of these drugs continues to rise, though more prospective studies are still needed to clarify the mechanisms behind these associations