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To dissect the upstream regulatory mechanism of miR-29b-3p under Gln deprivation conditions, we integrated transcriptome data (GSE148016) from both Gln+ and Gln- groups, and performed cross-analysis with the predicted upstream transcription factors of miR-29b-3p, ultimately identifying five candidate transcription factors

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The biological evaluation of the newly synthesized chemical agents demonstrated that molecule 63 possesses the most potent enzyme inhibition activity, with an IC 50 of 17.7 M (Figure 7)

Cells treated with MRTX1133 for indicated times (10 mM)

doi: 10.1136/gutjnl-2017-315136 107 ZhuangX.TianZ.LiL.ZengZ.ChenM.XiongL