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Animal experiments have demonstrated that high-fat diet downregulates tight junction protein expression (such as occludin and ZO-1), reduces mucus layer thickness, and increases intestinal permeability ( Metabolic endotoxemia refers to a state of chronically elevated circulating LPS levels caused by diet (particularly high-fat diet) ( This inflammatory state further damages intestinal barrier function, forming a vicious cycle

The dependence for haem-iron at all stages of NTHi pathogenesis exposes a vulnerability that provides promising targets for the development of new therapies that may disrupt iron uptake (Stites et al., 1999

Treatment of hyperpigmentation with glutathione by the orobuccal route using hydroxypropyl cellulose (HPC) film was reviewed to formulate clinical guidance from published data

Arch Toxicol 98:23932408

25 Patients diagnosed with vitamin B 12 deficiency whose history and physical examination do not suggest an obvious dietary or malabsorptive etiology should be tested for pernicious anemia with anti-intrinsic factor antibodies (positive predictive value = 95%), particularly if other autoimmune disorders are present