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Glutamine can serve as a precursor for aspartate through the concerted actions of glutaminase, yielding glutamate, followed by transfer of the nitrogen from glutamate to oxaloacetic acid (OAA) forming aspartate

Oxidative Medicine and Cellular Longevity (2012) 4

Beyond HMGB1 signaling, ferroptotic cells activate other molecular inflammatory pathways, triggering inflammatory reactions and the recruitment of macrophages

In animal models of HD, atrophic astrocytes in striatum retract their leaflets from cortico-striatal synapses, which are known to be affected in the early HD

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