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Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated average reductions in body weight exceeding 20% over 48 weeks in some participants

Decreased intrarenal carnitine content in cKOt mice in parallel with decreased OCTN2 expression and increased fractional carnitine excretion in the urine suggested an impaired apical entry of carnitine in the proximal tubule rather than dysregulation of basolateral carnitine transport

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Not only did Hanes beat his recent best by more than 10 minutes, but he also ran the age-graded equivalent of 2:10:56