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[2] joint hypermobility (stretch further than normal) loose/unstable joints, prone to subluxations/dislocations joint pain joints that move beyond the normal range (hyperextensibility) early onset of arthritis soft, velvety-like skin fragile skin that tears or bruises easily severe scarring slow and poor wound healing development of molluscoid psuedo tumors musculoskeletal pain poor muscle tone (less common) Subtypes There are currently thirteen sub-types of EDS

10.1038/s12276-023-01047-4 58 JensterleM.KravosN

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The GIPR missense variant, rs1800437, has been associated with a large number of traits in the public domain, including BMI and body mass phenotypes, T2D, blood glucose and a number of metabolic or haematologic traits including blood pressure, reticulocyte and/or erythrocyte volume and urinary calculus (Supplementary Table 18)