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A potent antioxidant, it successfully defends against free radical damage like UV exposure and pollution

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29 Due to its importance in the synthesis of myelin and neurotransmitters, as well as in keeping homocysteine levels low, all of which are associated with cognitive function, B12 has been studied for a potential role in cognitive function

In particular, it reduced the intratumoral infiltration G-MDSCs and the expression of protumor immunosuppressive molecules including arginase 1, iNOS, IDO and S100A8 + A9, which was accompanied by increased cytotoxic cell infiltration (80)

Surgical removal of these TDLNs abolished PD-1/PD-L1 checkpoint blockade-induced tumor regression and was associated with decreased immune infiltration in the primary tumors (34)