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What they still lack is only expected at this stage, the durability of data beyond two years, and head-to-head outcome comparisons against semaglutide (Wegovy) and tirzepatide (Mounjaro)

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Response: We appreciate the commenter for sharing their recommendation that we use prospective peer-grouped benchmarks with case-mix stratification and regional price standardization to limit cost differences in high-acuity versus community practices

The authors noted that the quality of included RCTs was heterogeneous

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