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Interchangeability and the Automatic Substitution Question A biosimilar can be approved as biosimilar without being designated interchangeable. Interchangeability requires additional evidence that the biosimilar can be substituted for the reference biologic without increased risk compared to using the reference product alone, and without involvement of the prescribing physician [41]

TrkA, tyrosine kinase A

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Its long-lasting action facilitates tracking of metabolic changes over time

Rapid weight loss associated with the drug has also led to facial aging (some in the public call this Ozempic face), in which sagging skin from the overall weight loss can affect facial appearance