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In cancer cells, elevated GSH levels are essential for scavenging excess reactive oxygen species (ROS) and detoxifying endogenous and exogenous electrophiles via free thiol groups, rendering GSH a promising therapeutic target

It could be that, given more [observational] time, they would have gone back to their baseline weight, says Nia Schwann Mitchell, an associate professor of medicine and a medical weight management specialist at Duke University

Hormonal shifts that occur throughout perimenopause and menopause, including declining estrogen and progesterone levels, can significantly disrupt metabolism, increase insulin resistance, and make fat loss far more difficult through lifestyle changes alone

Some patients switch to non-oral birth control methods (patch, injection, IUD) to avoid this interaction entirely

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