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Chronic hypercortisolism exposure has particularly significant damaging effects on the hippocampus, leading to neuronal dendritic atrophy, reduced synaptic density, and neurogenesis inhibition, resulting in an average 810% reduction in hippocampal volume in depression patients ( Cortisol damages the CNS and has widespread effects on the gut

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Inhibitory effects induced by Vicia faba, Uncaria rhyncophylla, and Glycyrrhiza glabra water extracts on oxidative stress biomarkers and dopamine turnover in HypoE22 cells and isolated rat striatum challenged with 6-hydroxydopamine

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