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Neuromodulation J Int Neuromodulation Soc 25(4):624632

Still, its a hypothesisnot a proven mechanism in our study. Future studies, especially those using more recent and more potent GLP-1 RAs such as high-dose semaglutide or tirzepatide, may offer further clarity

Currently, multiple phase 3 trials with oral semaglutide and orforglipron are ongoing for different populations (NCT05803421), while another oral GLP-1 RA (CT-996) is in early phase clinical trials (Table 1)

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These metabolic improvements often occur within weeks, before significant weight loss becomes visible