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Studies have shown that asymptomatic individuals with hyperuricemic already exhibit subclinical inflammation (e.g., elevated IL-6 and CRP), whereas acute gout flares are characterized by significant increases in IL-1 and S100A8/A9 levels, which may serve as distinguishing biomarkers (Ohashi et al., 2024

[136] In the 1940s it was generally dismissed as superstition

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It is primarily employed to reconstitute powdered drugs such as peptides, hormones, and various antibiotics