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In one embodiment, the buffer is a sodium bicarbonate buffer having a pH of about 6.5 to about 8.5, or about 7.0 to about 8.0

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In fact, a genetic variant in the HDC gene that reduces histamine levels is linked to a significantly decreased risk of chronic heart failure.[ref] Additionally, clinical trials show that blocking the H2 receptor is beneficial for chronic heart failure

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Summary Novo Nordisk will report the topline results from the REDEFINE-1 trial of CagriSema in obese patients before the end of the year