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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

Int J Radiat Oncol Biol Phys 74(2):482-9, 2009

GHS-R1a antagonists decrease food intake acutely in lean, diet-induced obese and ob/ob mice, and repeated administration to ob/ob mice leads to reduced weight gain

Window Weeks 5-8 What is commonly reported Body composition shifts begin (lean mass, fat distribution)

The primary endocrine manifestations of IBD include growth failure, metabolic bone disease, alterations in lipid and carbohydrate metabolism, pubertal delay, and hypogonadism (237)