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Indeed, in CA1 interneurons in the hippocampus, afferent tetanization induced LTD that could spread to nonactivated synapses (McMahon and Kauer, 1997) or induce plastic changes that lack input-specificity with LTP, LTD, or no changes occurring in both homosynaptic and heterosynaptic pathways in all possible combinations (Cowan et al., 1998)