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By contrast, rare truncating or severe missense variants across catalytic or regulatory domains underlie classical MTHFR deficiency (75-77)

In a separate liver fat substudy, the highest doses reduced liver fat by over 80 percent within 24 weeks, and up to 93 percent of participants with fatty liver disease saw their levels return to normal

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Endocrine 48(1):107115 Chai S, Liu F, Yang Z, Yu S, Liu Z, Yang Q, Sun F (2022) Risk of fracture with dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis combining 177 randomized controlled trials with a median follow-up of 26 weeks

In terms of clinical outcomes , head-to-head trials have demonstrated efficacy differences between tirzepatide and selective GLP-1 receptor agonists