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Secondly, when canine Purkinje fibers are co-treated with LCACs and another metabolite, lysophosphatidylcholine, the combined electrophysiological effects of the amphiphiles are analogous to those induced by comparable concentrations of each metabolite alone ( Opposing these findings of membrane perturbation and potentially irreversible sarcolemma disruption are the reports of reversible electrophysiological and inotropic effects following exogenous LCACs wash out or after/during normoxic reperfusion post ischemia (Sakata et al., 1989)

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